【摘要】 目的:探讨大肠癌组织中Caveolin-1和EGFR蛋白表达的变化。方法:采用免疫组织化学SP法对外科手术切除的126例大肠癌标本及35例癌旁正常黏膜组织进行Caveolin-1和EGFR蛋白检测。结果:大肠癌组织与癌旁正常黏膜组织中Caveolin-1蛋白阳性表达率分别为30.16%(38/126)和85.71%(30/35),EGFR蛋白阳性表达率分别为61.11%(77/126)和8.57%(3/35),2组间差异均有统计学意义(P<0.01)。大肠癌组织中Caveolin-1和EGFR蛋白的表达均与组织学类型无关(P>0.05),但与分化程度、淋巴结转移以及临床分期有关(P<0.05)。大肠癌组织中Caveolin-1与EGFR蛋白的表达呈负相关(rs=-0.327,P<0.05)。结论:大肠癌的发生发展过程中Caveolin-1和EGFR可能发挥重要作用。更多还原

【Abstract】 Aim: To investigate the expression of Caveolin-1 and EGFR proteins in colorectal carcinoma tissue. Methods:The expression of Caveolin-1 and EGFR proteins in 126 cases of colorectal carcinoma tissues,35 para-carcinoma normal mucosa tissues were detected using immunohistochemical method. Results: The positive rates of Caveolin-1 and EGFR in colorectal carcinoma tissue were 30.16%(38/126) and 61.11%(77/126), respectively, which significantly differed from those in normal mucosa tissues 85.17%(30/35) and 8.57%(3/35)(P<0.001 ). The expression levels of the two proteins in colorectal carcinoma tissue were not related to the histopathologic type(P>0.05 ), but correlated with malignant degrees,lymph node metastasis and clinical stages (P<0.05).The expression of Caveolin-1 in colorectal carcinoma tissue was negatively correlated with that of EGFR(P<0.05).Conclusion: The expression levels of Caveolin-1 and EGFR proteins are remarkably related to the progression and tumor metastasis.更多还原