【摘要】 目的:观察类风湿性关节炎(RA)患者治疗前后血清骨钙素(BGP)及肿瘤坏死因子α(TNF-α)水平的变化特点。方法:45例RA活动期患者经抗风湿治疗达缓解,治疗前后收集患者血液,分别采用放免法和酶免法测定血清BGP和TNF-α水平。以30例健康体检者为对照。结果:与对照组比较,RA患者治疗前血清BGP水平较低,TNF-α水平较高(P<0.05);治疗后RA患者血清BGP及TNF-α水平与对照组比较,差异无统计学意义(P>0.05)。结论:RA活动期有骨质破坏及骨吸收现象;TNF-α分泌增加,可能与RA的发生及进展有关。更多还原

【Abstract】 Aim: To study the changes of serum bone glaprotein (BGP) and tumor necrosis factor-α (TNF-α) levels in patients with rheumatoid arthritis (RA). Methods:The levels of serum BGP and TNF-α in 45 patients with RA were tested by RIA and EIA after and before treatment, and 30 normal individiuls were the control. Results: Compared with those of the control, the level of BGP of RA patients was lower before treatment, and that of TNF-α was higher (P<0.05). After treatment, the levels of serum BGP and TNF-α of RA patients didn’t differ from those of the control (P>0.05). Conclusion: There exists bone damage and bone reduce in patients with active phage RA. TNF-α secretion increase may be closely related to the occurence and progress of RA.更多还原