【摘要】 生物碱加兰它敏为可逆性乙酰胆碱酯酶(AChE)的抑制剂,对阿尔海默氏老年痴呆症有较好的疗效,介绍了以K3[Fe(CN)6]、钯络化物、三价碘化物等为氧化剂的氧化关环方法合成加兰它敏的方法,并总结了各种其外消旋体的拆分方法,简要评价了各种方法的优缺点。更多还原

【Abstract】 The natural alkaloid galanthamine which acts as a inhibitor of acetylcholine esterase,is a new drug for curing Alzheimer’s disease. The synthesis methods of galanthamine via phenolic coupling step using K3 Fe(CN)6 ,palladium-complex and iodine(Ⅲ)reagent as oxidant were introduced,and racemic resolution methods for galanthamine were summarized. Findlly,their advantage and disadvantage of synthetic and resolutions methods of galanthamine were put forwarded.更多还原