节点文献
加兰它敏(Galanthamine)的合成方法
Research Progress on Synthesis Methods of Alanthamine
【摘要】 生物碱加兰它敏为可逆性乙酰胆碱酯酶(AChE)的抑制剂,对阿尔海默氏老年痴呆症有较好的疗效,介绍了以K3[Fe(CN)6]、钯络化物、三价碘化物等为氧化剂的氧化关环方法合成加兰它敏的方法,并总结了各种其外消旋体的拆分方法,简要评价了各种方法的优缺点。
【Abstract】 The natural alkaloid galanthamine which acts as a inhibitor of acetylcholine esterase,is a new drug for curing Alzheimer’s disease. The synthesis methods of galanthamine via phenolic coupling step using K3 Fe(CN)6 ,palladium-complex and iodine(Ⅲ)reagent as oxidant were introduced,and racemic resolution methods for galanthamine were summarized. Findlly,their advantage and disadvantage of synthetic and resolutions methods of galanthamine were put forwarded.
【关键词】 加兰它敏;
阿尔海默氏;
乙酰胆碱酯酶抑制剂;
【Key words】 galanthamine; Alzheimer’s disease; acetylcholinesterse inhibitor(AChE);
【Key words】 galanthamine; Alzheimer’s disease; acetylcholinesterse inhibitor(AChE);
- 【文献出处】 精细化工中间体 ,Fine Chemical Intermediates , 编辑部邮箱 ,2007年02期
- 【分类号】TQ464.4
- 【被引频次】1
- 【下载频次】172