【摘要】 以对叔丁基溴苯为原料,在氮气保护下,通过格氏反应合成了对叔丁基苯硼酸,考察了温度、反应时间和物料配比等因素对收率的影响,优化合成条件为:n(对叔丁基溴苯)∶n(硼酸三甲酯)=1∶1.5,反应温度为-20～-30℃,反应时间140min,总收率69.5%。质谱和核磁共振光谱分析表明所得产物与目标产物结构一致。更多还原

【Abstract】 4-Tert-butylphenylboronic acid was synthesized with trimethyl borate and Grignard reagents which was prepared with 1-bromo-4-tert-butylbenzene and metal magnesium as raw materials under N2. An optimized process was obtained as follows: 1.5∶1molar ratio of 1-bromo-4-tert-butylbenzene to trimethyl borate,the temperature -20～-30℃,and the reaction time 140min. The final yield was 69.5%. The product was identified by mass spectrum and HNMR?更多还原