【摘要】 目的探讨颅内肿瘤放疗后磁共振质子波谱(1HMRS)的变化。方法选择需行放疗的颅内肿瘤患者40例,在放疗前后分别观察和测量肿瘤和对侧正常组织的N乙-酰天冬氨酸(NAA)、肌酐(Cr)、乳酸-脂质(Lac-L ip)峰值。计算肿瘤组织放疗前后的NAA/Cr、Cho/C、rCho/NAA的比值。结果颅内肿瘤放射治疗后,1HMRS均表现为Cho明显降低,NAA、Cr下降,Cho/Cr下降最明显,放射性坏死1HMRS表现出Lac-L ip峰。结论1HMRS可评估颅内肿瘤放疗后的代谢变化,是一种判断疗效有价值的检查方法。更多还原

【Abstract】 Objective To study the changes of proton MR spectroscopy in the intracranial tumors after radiotherapy.Methods Forty patients with intracranial tumors underwent multivoxel proton MR spectroscopic examination before and after radiotherapy respectively.The concentrations of NAA,Cho,Cr,Lac-Lip were obtained in the tumors and the contralateral normal brain region.The rates of NAA/Cr,Cho/Cr,Cho/NAA were calculated at the same time.Results After radiotherapy,tumors inhibited by radiation had decreased Cho,NAA and Cr on proton MRS.Tumor radiation necrosis showed high Lac-Lip peak on proton MRS.Conclusions Multivoxel proton MR spectroscopy was(available) for study of tumor metabolites after radiotherapy and it was(a valuable) method in evaluation of treating tumors after radiotherapy.更多还原