【摘要】 目的研究醇酸涂料释放挥发性有机化合物对小鼠脑组织神经递质含量的影响。方法将56只二级BALB/c小鼠随机分成7组(对照组,3d染毒组,6d染毒组,8d染毒组,10d染毒组,20d恢复组,30d恢复组),每组8只。采用动式吸入染毒的方法(醇酸涂料释放挥发性有机化合物浓度为30mg/m3),测定连续染毒期及恢复期小鼠脑组织乙酰胆碱、单胺类(多巴胺、5-羟色胺、去甲肾上腺素、肾上腺素)、氨基酸类(谷氨酸、天冬氨酸、甘氨酸、γ-氨基丁酸)神经递质的变化规律。结果在接触挥发性有机化合物的过程中,在染毒第3、6、8、10天,小鼠脑组织中乙酰胆碱、多巴胺、5-羟色胺、去甲肾上腺素含量低于对照组,差异均有统计学意义(P<0.05,P<0.01);在染毒第8、10天,小鼠脑组织中谷氨酸含量显著低于对照组,差异均有统计学意义(P<0.01);小鼠脑组织中甘氨酸在染毒第6、8、10天、γ-氨基丁酸在染毒第3、6天含量高于对照组,差异均有统计学意义(P<0.05,P<0.01)。脱离该环境后去甲肾上腺素含量仍然不能恢复到正常水平(P<0.01)。结论醇酸涂料释放挥发性有机化合物能够造成小鼠脑组织神经递质的改变。更多还原

【Abstract】 Objective To investigate the effects of volatile organic compounds escaped from alkyd dope on neurotransmitter content in the brain of mice.Methods 56 BALB/c mice were randomly divided into 7 groups,8 in each and exposed to volatile organic compounds(30 mg/m3)escaped from alkyd dope by dynamic inhalation exposure.The neurotransmitters(cholines,monoamines,amino acids)in the brain were determined during the period of exposure and comeback.Results Compared with the control,DA,5-HT,NE and Glu significantly decreased and Gly,GABA significantly increased during the period of exposure,however NE still kept significant decrease during the period of comeback.Conclusion Volatile organic compounds escaped from alkyd dope may cause neurochemical change in mice.更多还原