节点文献

新型凋亡显像剂^99mTc-FM-2的制备及生物分布

Preparation and biodistribution of new apoptosis imaging regent ^99mTc-FM-2

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 JI Shundong1 FANG Wei3 ZHOU Jundong2 HE Zuoxiang3 LIU Xiujie3 RUAN Changgeng1 ZHAO Ming4 1 (Jiangsu Institute of Hematology, Suzhou University First Affiliated Hospital, Suzhou 215006) 2 (Department of Nuclear Medicine, Suzhou Hospital, Suzhou 215004) 3 (Department of Nuclear Medicine, Fu wai Hospital, CAMS and PVMC, Beijing 100037) 4 (Medical School of Wisconsin University, WS. U.S.A.)

【机构】苏州大学附属第一医院江苏省血液研究所；中国医学科学院阜外心血管病医院；苏州市市立医院核医学科；苏州大学附属第一医院；江苏省血液研究所；美国威斯康星大学医学院；苏州215006；北京100037；苏州215004；威斯康星美国；

【摘要】用2-亚氨基噻吩盐酸盐(2-IT)修饰FM-2。用99mTc-GH转换络合标记法标记IT-FM-2,放化纯可达95%,且室温下可稳定8h以上。小鼠体内分布研究表明99mTc-FM2在体内主要通过肝、肾清除。正常心肌组织摄取率高、清除快。更多还原

【Abstract】 FM-2 was modified with 2-iminotholane and labeled with 99Tcm-GH. The radiochemical purity of 99mTc-FM-2 was over 95% and can stable in the routine temperature for more than 8 hours. Biodistribution in mice showed 99mTc-FM-2 was cleared mainly by liver and kidney. The normal myocardial showed a high uptake and rapid clearance of 99mTc-FM-2.更多还原