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两种微囊化β-胡萝卜素干粉在水中的溶解性能

Dissolution characteristics of two kinds of microencapsulated β-carotene powder in water

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【作者】 许新德姚善泾邵斌

【Author】 XU Xinde1,2,YAO Shanjing1,SHAO Bin2(1Department of Chemical and Biochemical Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China;2Zhejiang Medicine Co.Ltd.Xinchang Pharma.Factory,Xinchang 312500,Zhejiang,China)

【机构】 浙江大学化学工程与生物工程学系浙江医药股份有限公司新昌制药厂 浙江杭州310027浙江医药股份有限公司新昌制药厂浙江新昌312500浙江杭州310027

【摘要】 溶解性能是粉粒状物质的一个重要理化指标,但在测量过程中由于细小微粉易结“团块”并黏附在器壁或搅拌桨上,会影响测量结果。本研究自行设计了一个新的实验装置,以水分散液色度作为监控指标,可以准确地测定微囊化β-胡萝卜素干粉在水中的溶解性能。通过分析其溶解动力学和溶解活化能,找出了其溶解行为的限速因子,并提出了改善其溶解性能的对策,对优化微囊化β-胡萝卜素干粉的配方具有很好的指导意义。

【Abstract】 Dissolution characteristics is an important index for soluble powder,however,the experimental results are always irreproducible because of the fine powder’s lump-formation or conglutination tendency.In this work,a simple apparatus for determining the dissolution properties of soluble β-carotene powder was designed and set up to resolve these problems.Through monitoring the increase in solution chroma,the dissolution characteristics of two kinds of microencapsulated β-carotene powder in water were investigated,and a parameter for the deliquescent portion was determined as a function of time.Relative dissolution curves were plotted and dissolution kinetics as well as dissolution activation energy were analyzed.Based on the key factors for powder dispersion or dissolution obtained,this method can be used to improve the dissolution abilities.

【基金】 国家自然科学基金项目(20576118)~~
  • 【文献出处】 化工学报 ,Journal of Chemical Industry and Engineering(China) , 编辑部邮箱 ,2007年07期
  • 【分类号】TQ460.1
  • 【被引频次】2
  • 【下载频次】316
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