【摘要】 以聚乙二醇作为可溶性聚合物载体,得到了聚乙二醇支载的的邻叠氮苯甲酸酯,与炔酯发生1,3-偶极环加成反应后,以KCN作为解脱剂,从聚乙二醇上解脱得到1,2,3-三唑化合物,具有较好的产率,经红外、核磁及元素分析等检测,所得数据与其结构相符.更多还原

【Abstract】 An efficient method to synthesize 1,2,3-trizoles has been developed using poly(ethylene glycol) as soluble polymer support.Poly(ethylene glycol)(PEG) stepwise reacted with o-azidobenzoic acid ester,acetylenic ester to produce the corresponding PEG-bound 1,2,3-trizoles through 1,3-dipolar cycloaddition.After cleavage from the polymer in the presence of KCN and methanol,afforded 1,2,3-trizole derivatives in good yields and high purity.The structure of target molecule was detected by IR,H1 NMR,C13 NMR and EA.更多还原