【摘要】 以3-硝基邻苯二甲酸为原料,经脱水、傅克酰基化、还原、重氮化、水解和环合反应合成了大黄酚(6),总收率40.4%。6再经乙酰化、氧化、脱乙酰化反应合成了大黄酸(8),总收率22.3%。6和8的结构经1H NMR表征。更多还原

【Abstract】 Chrysophanic acid(6) in total yield of 40.4% was synthesized from 3-nitrophthalic acid by dehydration,Friedel-Crafts acylation,reduction,diazotization,hydrolysis and cyclization.Rhein(8) in total yield of 22.3% was synthesized from 6 by acylation,oxidation and deacetylation.The structures of 6 and 8 were characterized by 1H NMR.更多还原