【摘要】 目的探讨血管内皮生长因子(VEGF)及其受体Flk-1在大肠癌发生中的作用。方法采用免疫组化技术检测正常大肠粘膜15例(NM组)、大肠腺瘤27例(Ad组)、大肠癌81例(CC组)中VEGF及其受体Flk-1的表达。结果从NM到Ad到CC组VEGF及其受体Flk-1的表达逐渐增高、增强组间均存在显著差异(P均<0.01)。结论VEGF及其受体Flk-1可作为大肠正常组织恶变的不良信号,检测VEGF及其受体Flk-1可作为预测组织恶变的参考指标。更多还原

【Abstract】 Objective To investigate the significance of VEGF and its receptor Flk-1 expression in normal mucosa (NM),adenoma and colorectal carcinoma(CC). Methods SP immunohistochemical staining was used to examine expressions of VEGF, Flk-1 among 15 cases of NM,27 cases of Ad and 81 cases of CC paraffin-embedded specimens. Rank sum test was used to analyze the expressions of VEGF and Flk-1.Results The expression of VEGF and Flk-1 from NM to Ad to CC appeared an upward tendency. There were significant differences in VEGF and Flk-1 expression between the two groups(P<0.01,P<0.01). Conclusions VEGF,Flk-1 as bad signals in the occurrence of CC could be regarded as predictive factors of CC.更多还原