【摘要】 对苯醌与乙酸酐经1,4-加成生成1,2,4-苯三酚三乙酸酯,然后与苹果酸反应经水解、环合反应得6,7-二羟基香豆素,再经甲基化得到6,7-二甲氧基香豆素,总收率为74.4%,整个过程反应条件温和,操作方便,适合工业生产的要求,对产品结构进行了IR和1HNMR表征。更多还原

【Abstract】 Hydroxyquinol triacetate was prepared from p-benzoquinone by 1,4-addition reaction with acetic anhydride and then 6,7-dihydroxy coumarin was synthesized from it by hydrolyze and cyclization in concentrated sulfuric acid.Then 6,7-dimethoxy coumarin was synthesized by methylating from 6,7-dihydroxy coumarin with an overall yield of 74.4%.The procedure was practical.Its structure was confirmed by IR and 1HNMR.更多还原