【摘要】 目的:探讨泮托拉唑与多潘立酮联用治疗胃食管反流病的效果。方法:胃食管反流病66例,采用随机、双盲法分成两组,治疗组34例,给予泮托拉唑20 mg,2/d,多潘立酮10 mg,3/d,口服。对照组32例,给予法莫替丁20 mg,2/d,多潘立酮10 mg,3/d,口服。于治疗后2、4、6周观察胃灼热、反酸、胸骨后痛等症状的缓解情况,并于6周后复查胃镜观察食管炎治愈率。结果:治疗组治疗2、4、6周后总有效率分别为79.41%、85.29%、94.12%,对照组治疗2、4、6周后总有效率分别为56.25%、65.63%、68.75%,两组比较有极显著性差异(P<0.01);治疗组治疗6周后内镜下A、B、C-D级食管炎治愈率分别达81.25%、71.43%、75.00%,对照组治疗6周后内镜下A、B级食管炎内镜下治愈率分别为40.00%、30.77%,C-D级食管炎治愈率为零,两组比较有极显著性差异(P<0.01)。结论:泮托拉唑与多潘立酮联用是治疗胃食管反流病的有效方案。更多还原

【Abstract】 Objective:To investigate the curative effect of pantoprazole and domperidone on gastroesophageal reflux disease(GERD).Methods:66 patients with GERD were randomly divided into two groups,including 34 in pantoprazole group who were given Pantoprazole 20 mg twice daily and Domperidone 10 mg three times daily,and 32 in famotidine group who were given Famotidine 20 mg twice daily and Domperidone 10 mg three times daily.Major symtoms were evaluated and cure rate of esophagitis was monitored under gastroscope.Results:The cure rate of the pantoprazole group was 79.41%、85.29%、94.12% respectively after 2、4、6 weeks of treatment,but the cure rate of the control group was 56.25%、65.63%、68.75%,showing an obvious difference(P<0.01);the cure rate of patients with grade A、B、C-D of esophagitis was monitored under gastroscope in pantoprazole group,which was 81.25%、71.43%、75.00% respectively after 6 weeks of treatment,but the rate of the famotidine group were 40.00%、30.77% and zero in C-D Grade with an obvious difference(P<0.01) between the two groups.Conclusion:Pantoprazole plus Domperidone is more effective than Famotidine plus Domperidone in the treatment of GERD.更多还原