【摘要】 目的:观察区域性灌注新辅助化疗对晚期乳腺癌患者腋窝淋巴结状态的影响,以探讨区域性动脉灌注化疗对晚期乳腺癌的治疗意义。方法:对38例Ⅲ~Ⅳ期乳腺癌行内乳动脉置管并连续灌注新辅助化疗,3周后行手术切除(治疗组)并与未化疗直接手术(对照组)的34例乳腺癌比较,观察腋窝淋巴结的变化。结果:治疗组检出腋窝总淋巴结和阳性淋巴结为(16.8±6.1)枚和(3.3±1.9)枚,显著低于对照组的(22.9±4.8)枚和(5.6±3.0)枚(P<0.05)。结论:内乳动脉置管灌注新辅助化疗可使腋窝阳性淋巴结数明显减少。更多还原

【Abstract】 Objective:To evaluate the effects of neoadjuvant chemotherapy via arterial infusion in the treatment of advanced breast cancer.Methods:Thirty-eight patients with advanced breast cancer were subjected to neoadjuvant chemotherapy via arterial infusion(Combination Group).The operation was performed 3 weeks later.Compared with the thirty-four patients with breast cancer treated with initial surgery only(Surgery Group) axillary lymph node status was in spected.Results:The numbers of total and positive lymph nodes in the Combination Group(16.8±6.1,3.3±1.9) were significantly fewer than that in the Surgery Group(22.9±4.8,5.6±3.0)(t=-1.866,P=0.005;t=2.467,P=0.006).Conclusion:Positive axillary lymph nodes retrieved after axillary lymph node dissection decrease in number after neoadjuvant chemotherapy via arterial infusion in advanced breast cancer patienfs.更多还原