【摘要】 目的以C57BL/6小鼠为动物模型,观察水溶性米诺地尔(Water-soluble Minoxidi,WMD)洗剂对毛发生长及毛发生长周期的影响。方法采用松香∶蜡(1∶1)混合物脱毛法诱导小鼠体毛由休止期进入生长期。脱毛次日,实验组小鼠每日分别以1%WMD、1.5%WMD和3%WMD洗剂擦洗脱毛区,连续21 d,记录小鼠皮肤颜色变化过程及新生毛发生长状况评分分值,并检测WMD对新生毛长、新生毛重、真皮厚度及毛囊数目的影响。结果与对照组小鼠相比,给药组小鼠皮肤颜色提前24h由粉红色变为黑色,推迟48h由黑色变为灰色;除毛重外,实验组小鼠毛长、真皮厚度及毛囊数目在统计学上均与模型组小鼠具有显著性差异,且1.5%WMD组小鼠结果最为明显。结论WMD可诱导和延长毛发生长期,推迟毛发退行期,促进C57BL/6小鼠毛发生长。更多还原

【Abstract】 OBJECTIVE To observe the effects of watersoluble minoxidil(WMD) on hair growth and hair cycle of C57BL/6 mouse alopecia model.METHODS Anagen was induced over the back of telogen mice by depilation of hair shafts with wax∶resin(1∶1) mixture.The experimental mice were treated tropically once daily using respectively 1% WMD,1.5%WMD and 3% WMD for 21 days,meanwhile the daily changes of skin color and the score of the final hair growth characteristic were observed.Furthermore,the effects of WMD on hair growth were evaluated by measuring hair weight and length,dermis thickness and the number of follicle in mice.RESULTS The skin color of experimental mice turned from pink to black is 24h earlier than that of control mice,and gray from black delay 48h compared with that of the latter.Moreover,it was remarkable difference in statistics of hair length,dermis thickness and the number of follicle except hair weight in experimental mice compared with model mice,and it was expecially obvious in 1.5%WMD group.CONCLUSION WMD not only can induce and prolong anagen,but also postpone catagen in C57BL/6 mice.Moreover,WMD can promote hair growth of experimental mice.更多还原