【摘要】 目的:观察不同国产止吐药预防头颈部癌含顺铂(cisplatin,DDP)方案化疗引起的恶心、呕吐的临床疗效和不良反应。方法:63例患者采用含DDP方案化疗90周期,随机分为3组,各化疗30周期,分别给予国产恩丹西酮(欧贝)、格拉司琼(琼沙奥或君凯)、托烷司琼(赛格恩)预防恶心、呕吐反应。结果:防治恶心、呕吐的有效率格拉司琼组为93.3%,托烷司琼组为86.7%,恩丹西酮组为83.3%,3组之间疗效比较差异无显著性;3种止吐药毒副反应相似,以便秘、倦怠及头痛多见,但程度较轻。结论:国产恩丹西酮、格拉司琼、托烷司琼均为头颈部癌含DDP方案化疗的有效止吐药,其疗效相似,不良反应轻,病人可耐受。更多还原

【Abstract】 Objective: To evaluate the clinical efficacy and adverse effects of three 5-HT3 antagonists(granisetron,tropisetron,and ondansetron that produced in china) for the prevention of cisplatin-induced nausea and emesis in patients with head and neck cancers.Methods: Sixty-three patients that treated with high dose(80-100 mg/m2) of cisplatin for 90 cycles following chemotherapeutic regimens were ramdomly divided into three groups to receive antiemetic drugs including granisetron,tropisetron,and ondansetron.Results: The efficacy rates of granisetron,tropisetron,and ondansetron were 93.3%,86.7%,and 83.3% respectively(P>0.05).Their side-effects were similar which were frequent constipation,fatigue and headache,but were mild and bearable.Conclusions: granisetron,tropisetron,and ondansetron are effective drugs in prevention of cisplatin-induced emesis in patients with head and neck cancers.更多还原