【摘要】 研究了由蒜头果油制取1,15-十五碳二酸二甲酯的3种合成路线,比较了3种合成路线中臭氧化的吸收特征。结果表明,合成路线一为5步反应,1,15-十五碳二酸二甲酯收率为26.9%;路线二为4步反应,1,15-十五碳二酸二甲酯收率为61.7%;路线三为3步反应,1,15-十五碳二酸二甲酯收率为68.1%。通过对比确定路线3是最佳合成方案。用拟水平正交试验法对路线3的酯化反应进行优化,确定最佳的反应条件是:反应温度70℃左右;催化剂用量与原料比为1∶5(v.m-1);反应时间2 h。该优化条件可使1,15-十五碳二酸二甲酯收率达到72.4%。更多还原

【Abstract】 Three kinds of synthesis process of dimethyl 1,15pentadecanedioate from malania oleifera oil were introduced and the absorption characteristic of reactant in the ozonidation reaction of these three kinds of synthesis process were compared.The routeⅠ had 5 steps reaction and its yield was 26.9%;the route Ⅱ had 4 steps and the yield was 61.7%;the route Ⅲ had 3 steps and the yield was 68.1%.The process route Ⅲ was the best synthesis process.The esterification condition of route Ⅲ was optimized by the quasi-level horizontal orthogonal testing method.The result showed the best esterification conditions were as followed: the reaction time 2h,reaction temperature 70 ℃,ratio of catalyst amount to raw material was 1∶5(v/m).The yield of dimethyl 1,15-pentadecanedioate by the optimized process could be up to 72.4%.更多还原