【摘要】 多药耐药(multidrug resistence,MDR)是肿瘤化疗失败的主要原因,多年来医学界一直致力于多药耐药机制的研究。神经酰胺信号系统在细胞凋亡中的作用逐渐引起人们的重视,神经酰胺是细胞凋亡过程中的第二信使,葡萄糖神经酰胺合成酶(glucosylceramide synthase,GCS)可以催化神经酰胺糖基化,使其转变为无细胞毒性的葡萄糖神经酰胺,进而促进鞘糖脂的合成,大量研究表明细胞内GCS水平的增高与MDR表型有关。更多还原

【Abstract】 Multidrug resistance is considered to be the main obstacle to the effective chemotherapeutic treatment, and has been investigated for years. The sphingolipid ceramide has now become a subject of considerable interest as an intracellular signaling molecule involved in the mediation of apoptosis. In addition to its role as a mediator of cell death, recent studies demonstrated that glucosylceramide synthase (GCS) can catalyze the glycosylation of ceramide, thereby converting it to non-cytotoxic glucosylceramide (GlcCer) and promoting the synthesis of sphingolipid. Elevated levels of GlcCer have been found to be related to the phenotypes of a number of multidrug-resistant human cancer cell lines.更多还原