【摘要】 目的观察阿伦膦酸钠治疗原发性骨质疏松症的疗效。方法选择原发性骨质疏松患者138例,年龄40～91岁,连续服用国产阿伦膦酸钠10mg/d,6～36月,观察治疗前后患者症状、骨密度变化和安全性。结果治疗后患者骨痛缓解,活动能力增加;骨密度明显上升,骨密度平均增长率分别为3.23%(Neck)、5.19%(Troch)、4.48%(Inter)、4.18%(Total)和11.59%(Ward’s);治疗期间新发骨折3例,再骨折率为2.17%;上腹部不适发生率为7.97%,坚持服药自行缓解。结论阿伦膦酸钠对原发性骨质疏松症具有缓解骨痛、提高生活质量、增加骨密度、降低再骨折发生的作用,是有效、安全的药物。更多还原

【Abstract】 Objective To test the efficacy of alendronate sodium in treatment of osteoporosis. Methods According to the diagnostic standard of the primary osteoporosis, we selected 138 cases with osteoporosis. They received alendronate 10 mg/d for 6~36 months. The efficacy was determined by the change of BMD and the improvement of clinical symptoms before and after the trial. Results Pain of the patients was relieved and the BMD was increased significantly. In period of treatment, the refracture rate was 2.17%, and no apparent serious adverse effects were observed. Conclusion Alendronate could relieve bone pain, increase BMD and prevent refracture in osteoporosis. It is an effective and safe treatment method for osteoporosis.更多还原