【摘要】 目的:观察石仙桃提取物对小鼠运动疲劳和缺氧的影响。方法:应用5种运动疲劳和缺氧实验,如:常压耐缺氧实验、特异性心肌缺氧实验、亚硝酸钠引起的缺氧实验、对抗脑缺血缺氧和耐力实验等。结果:①常压耐缺氧实验中,腹腔注射石仙桃提取物呈剂量依赖性,明显延长小鼠生存时间。②特异性心肌缺氧实验中,腹腔注射石仙桃明显延长小鼠生存时间。③在亚硝酸钠引起的缺氧实验中,预防性给石仙桃提取液可延长小鼠存活时间。④对抗断头术后脑缺血缺氧实验中,石仙桃提取液能显著性延长小鼠喘息时间。⑤在耐力实验中,石仙桃提取液呈剂量依赖性延长小鼠存活时间。结论:石仙桃具有抗疲劳作用、耐缺氧作用,其潜在的作用机制可能与提高肺泡液清除有关。更多还原

【Abstract】 Objective:To study the fatigue-resisting and anoxia-resisting effect of the abstract of Pholidota chinensis lindl on mice.Methods: there are 5 kinds of anoxia models,such as:the test of the tolerance to anoxia under normal pressures,the test of the specificity myocardium under hypoxia,the test of the antagonism of sodium nitrite,and the celebral hypoxia-ischemia test,and the test on exercise tolerance in mice.Results: ① In the study of extract on the ability of hypoxia endurance at normal pressure,result showed the mice survival time at normal pressure prolonged by extracts;② In the study of the effects of extract on specific anoxic myocardium.results showed the mice survival time prolonged by extracts;③ In the study protective effects of extract on survival time after peritoneal injection NaNO2 in mice.Iintraperitoneally treated with extracts;④ In the study of the effects of extract on cerebral ischemia and hypoxia after decapitation,the gasping duration was prolonged by extracts in mice;⑤In the test on exercise tolerance in mice.The result showed the survival time of the swimming was prolonged by extracts in a dose-dependent manner.Conclusion: pholidota chinensis lindl.has effects of anti-fatigue,anti-hypoxia through potential mechanism of the increase of alveolar fluid clearance.更多还原