【摘要】 目的提高硝苯地平的体外溶出速率。方法分别以聚乙二醇6000,聚乙二醇4000,聚乙烯吡咯烷酮K30,泊洛沙姆188为载体,用熔融法、溶剂法、溶剂-熔融法制备硝苯地平固体分散体。采用DTA法分析药物在固体分散体中的存在状态,并进行体外溶出速率试验。结果各种固体分散体均能加快药物的溶出速率,载体比例愈大,药物溶出越快。结论硝苯地平固体分散体比原料药的溶出速率显著提高。更多还原

【Abstract】 Objective To prepare nifedipine solid dispersions and investigate their dissolution rate.Methods PEG6000,PEG4000,PVPK30 and Poloxamer188 were used as carrier separately,then nifedipine solid dispersions were prepared by solvent method,melting method and solvent-melting method,separately.The distribution of nifedipine in carriers was determined by using differential thermal analysis.The dissolution rate of the solid dispersions was also detected.Results In vitro dissolution results showed that higher carrier-nifedipine ratio led to faster drug dissolution.Conclusion Nifedipine solid dispersions can increase the dissolution rate of nifedipine in vitro.更多还原