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3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成

Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene

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【作者】 关玉昆房丽晶唐志勇李裕林

【Author】 GUAN Yu-Kun1,2,FANG Li-Jing2,TANG Zhi-Yong2,LI Yu-Lin2(1.School of Pharmacy,Yantai University,Yantai 264005,China;2.State Key Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000,China)

【机构】 烟台大学药学院兰州大学功能有机分子化学国家重点实验室兰州大学功能有机分子化学国家重点实验室 烟台264005 兰州大学功能有机分子化学国家重点实验室兰州730000

【Abstract】 3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity.For the purpose of pharmacological activity research on natural product 1 and its derivatives,a facile total synthesis of compound 1 starting from(+)-dihydrocarvone(2) was completed in an overall yield of 24%.The structures of all intermediates and product 1 were confirmed via 1H NMR,13C NMR,MS and IR techniques.The NMR data of compound 1 are in agreement with those of natural products.

【基金】 国家自然科学基金(批准号:20272021);烟台大学博士科研启动基金资助
  • 【文献出处】 高等学校化学学报 ,Chemical Journal of Chinese Universities , 编辑部邮箱 ,2007年07期
  • 【分类号】O621.3
  • 【下载频次】154
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