节点文献
3-氧-11,12,13-三羟基桉烷-4-烯的简便全合成
Facile Total Synthesis of 3-Oxo-11,12,13-trihydroxyeudesm-4-ene
【Abstract】 3-Oxo-11,12,13-trihydroxyeudesm-4-ene(1) was a highly oxygenated natural eudesmane isolated from traditional herbal medicine with an antiphlogostic and spasmolytic activity.For the purpose of pharmacological activity research on natural product 1 and its derivatives,a facile total synthesis of compound 1 starting from(+)-dihydrocarvone(2) was completed in an overall yield of 24%.The structures of all intermediates and product 1 were confirmed via 1H NMR,13C NMR,MS and IR techniques.The NMR data of compound 1 are in agreement with those of natural products.
【关键词】 桉烷;
3-氧-11,12,13-三羟基桉烷-4-烯;
全合成;
倍半萜;
【Key words】 Eudesmane; 3-Oxo-11,12,13-trihydroxyeudesm-4-ene; Total synthesis; Sesquiterpene;
【Key words】 Eudesmane; 3-Oxo-11,12,13-trihydroxyeudesm-4-ene; Total synthesis; Sesquiterpene;
【基金】 国家自然科学基金(批准号:20272021);烟台大学博士科研启动基金资助
- 【文献出处】 高等学校化学学报 ,Chemical Journal of Chinese Universities , 编辑部邮箱 ,2007年07期
- 【分类号】O621.3
- 【下载频次】154