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新型仿生聚合物胶束用于纳米药物载体的研究
Novel Biomimetic Polymeric Micelles for Drug Delivery
【Abstract】 Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.
【关键词】 聚合物胶束；
细胞膜仿生；
药物缓释；
生物相容性；
磷酸胆碱；
【Key words】 Polymeric micelles； Biomimetic of cell membrane； Drug sustained release； Biocompatibility； Phosphorylcholine；
【Key words】 Polymeric micelles； Biomimetic of cell membrane； Drug sustained release； Biocompatibility； Phosphorylcholine；
【基金】 国家自然科学基金(批准号:50373036);教育部霍英东基金优选资助项目(批准号:J20040212)资助
- 【文献出处】 高等学校化学学报 ,Chemical Journal of Chinese Universities , 编辑部邮箱 ,2007年02期
- 【分类号】TQ460.4
- 【被引频次】38
- 【下载频次】1202