【摘要】 银泰(1-对羟基苯基丁酮)是以银杏外种皮提纯物白果酚为先导化合物仿生合成的一种杀菌剂。其中,银杏果实乙醇粗提物8.3倍和25倍液对苹果腐烂病抑菌率达100%和50%;银杏果实外种皮提纯物白果酚200倍和400倍液对苹果腐烂病病菌抑菌率均为100%。20%银泰微乳剂对苹果腐烂病、番茄灰霉病等4种病菌EC50为17.26~48.43mg/L,分别优于对照药剂;田间防治小麦纹枯病等4种病害效果达85%以上;对非靶标生物安全,且不易产生抗药性。仿生合成的银泰原药对大白鼠毒性试验,经口、经皮LD50均为4 640mg/kg,20%银泰乳油对大白鼠毒性试验,经口LD50为3 160mg/kg,经皮LD50为2 150mg/kg;亚慢性经口毒性(90 d)试验雌为19.1mg/kg,雄为18.3mg/kg;Ames、细胞微核和染色体畸变试验均为阴性结果。更多还原

【Abstract】 Yintai（p-hydroxy butrophenone） is a kind of bionic fungicides synthesized by simulating the lead compound of ginkgol isolated from the exosperm of ginkgo fruit.8.3-time diluted solution of alcohol crude extract from the ginkgo fruit showed 100% inhibtion on the pathogen of apple canker（Valsa mali）,and 50% inhibition for the 25-time solution.Both 200-time and 400 time solutions of ginkgol,extracted from external seed coat of ginkgo,had 100% inhibition on pathogen of apple canker（Valsa mali）.EC₅₀ of 20% Yintai ME against 4 kinds of pathogens,including apple canker,tomato gray mold,and so on,ranges from 17.26 mg/L to 48.43 mg/L,better than the contrast chemicals respectively.Field control effects on 4 kinds of diseases,e.g.,Rhizoctonia cerealis,are higher than 85%,with safety to non-target organisms,and no symptom of pesticide resistance.Both LD₅₀ of acute oral toxicity and LD₅₀ of acute dermal toxicity to mouse are （4 640 mg/kg） by Yintai technical material,and（3 160） mg/kg and（2 150） mg/kg by 20% Yintai EC coorespondingly.Trials of subchronic toxicity（90 days） revealed that oral toxicity was 19.1 mg/kg for female,and 18.3 mg/kg for male,with negative results on Ames test,micro-nucleus test,and chromosome-type aberration test.更多还原