【摘要】 丝裂酶原活化蛋白激酶(MAPK)是生物体内重要的信号转导系统之一。MAPK信号转导通路中3组分激活模件内的激酶,引发一系列的磷酸化级联反应,参与细胞的生长、发育、分裂、分化、死亡以及细胞间的功能等多种细胞过程。本文就MAPK信号转导通路的组成成分、调控方式和作用机制的研究现状作一综述,旨在为组织损伤程度和伤后时间推断的法医学研究提供参考资料。更多还原

【Abstract】 Mitogen-activated protein kinase(MAPK)is one of the important signal transduction systems in organism.The three-component module of MAPK,in which the protein kinases activate a successive phosphorylation cascade,is involved in many cellular processes,such as cell growth,development,division,differentiation,death and coordination of cellular processes.The components,regulation mode and mechanisms involved in the MAPK pathway are reviewed in the article,which may provide understanding for estimatiion of the degree of tissue lesion and wound age in forensic research.更多还原