【摘要】 目的探讨肠球菌溶血素与毒力的关系。方法比较溶血性肠球菌在临床标本及健康人群粪便标本的检出率;比较溶血性、非溶血性肠球菌对小鼠的LD50及其对9种抗生素的敏感性。结果临床标本肠球菌的溶血素检出率61.5%,高于健康人群粪便标本(18.4%,P<0.05);溶血性肠球菌的LD50[(3.9~11)×108cfu/mL]比非溶血性肠球菌小[(2.5~8.9)×1010cfu/mL,P<0.01]。除丁胺卡那、万古霉素外,溶血性肠球菌对抗生素的耐药性明显高于非溶血株。结论肠球菌的溶血素可能与其毒力有关。更多还原

【Abstract】 Objective To investigate the relation between enterococcus hemolysin and its virulence.Methods Incidence of hemolysin of enterococci derived from clinical isolates and healthy people fecal specimens were examined respectively;LD₅₀ and antibiotic susceptibilities were compared between hemolytic strains and non hemolytic strains.Results Strains derived from clinical isolates exhibited higher（61.5%） incidence of hemolysin than that from healthy people fecal speciments（18.4%,P<0.05）.The LD₅₀ of hemolytic strains \ were at least 10-fold higher than those of non-hemolytic strains\,P<0.01.Hemolytic strains were found to be more resistant to all the 9 antibiotics tested,except amikacin and vancomycin.Conclusion These results implied that hemolysin may contribute to the virulence of enterococci.更多还原