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非小细胞肺癌中COX-2蛋白对细胞凋亡的抑制作用

Suppression of COX-2 protein to cell apoptosis in non-small cell lung cancer

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【作者】 孙丽梅赵月王鲁建宋敏宋继谒

【Author】 SUN Limei, ZHAO Yue, WANG Lujian, SONG Min, SONG Jiye. Department of Pathology, China Medical University, Shenyang, Liao-ning 110001, P.R.China

【机构】 中国医科大学基础医学院病理学教研室中国医科大学基础医学院病理学教研室中国医科大学基础医学院人体解剖学教研室

【摘要】 背景与目的从凋亡的角度看,肿瘤的发生是由于凋亡机制受抑,从而使变异细胞积聚形成肿瘤。本研究的目的是探讨非小细胞肺癌组织中细胞凋亡和COX-2蛋白表达情况及其对预后的影响。方法应用DNA缺口末端标记技术和免疫组化方法检测111例非小细胞肺癌组织中细胞凋亡和COX-2蛋白表达水平,应用CD34标记血管来计数肿瘤组织的微血管密度。结果111例非小细胞肺癌中,COX-2蛋白阳性表达者75例(67.6%),细胞高凋亡水平者53例(47.7%)。COX-2蛋白的表达与肿瘤TNM分期(P=0.025)和淋巴结转移情况(P=0.018)有密切关系,且COX-2阳性表达的非小细胞肺癌组织中微血管密度明显高于阴性表达者(P=0.000)。COX模型多因素分析显示,淋巴结转移(P=0.006)和COX-2蛋白阳性表达(P=0.000)是非小细胞肺癌患者的不良预后因素。结论COX-2阳性表达可能抑制肿瘤细胞凋亡,可作为判断非小细胞肺癌患者预后不良的潜在指标。

【Abstract】 Background and objective One of mechanisms of carcinogenesis is suppression of cell apoptosis which leads to accumulation of aberrant cells. The aim of this study is to investigate cell apoptosis and COX-2 protein expression in non-small cell lung cancer (NSCLC). Methods Cell apoptosis, expression of COX-2 and microvessel density (MVD) were detcted in 111 NSCLC samples by TdT-mediated dUTP nick end labeling (TUNEL) technique and immunohistochemical staining. Results The positive rate of COX-2 protein expression was 67.6% (75/111), and there were 53 patients with high level cell apoptosis (47.7%). Expression of COX-2 protien was significantly related to TNM stages (P=0.025) and lymph node metastasis (P=0.018). The MVD in NSCLC tissues with positive COX-2 expression was significantly higher than that in negative expression ones (P=0.000). COX model showed that lymph node metastasis (P=0.006) and positive expression of COX-2 protein (P=0.000) were independent prognostic factors of NSCLC. Conclusion The expression of COX-2 protein may suppress cell apoptosis of tumor, and it may serve as a potential marker of prognosis for NSCLC.

  • 【文献出处】 中国肺癌杂志 ,Chinese Journal of Lung Cancer , 编辑部邮箱 ,2007年03期
  • 【分类号】R734.2
  • 【被引频次】7
  • 【下载频次】137
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