【摘要】 目的:探讨Fascin-1蛋白表达与结直肠癌发生及其生物学行为的关系.方法:应用免疫组化S-P法,检测结直肠癌80例、正常黏膜40例以及结直肠癌区域淋巴结转移癌37例Fascin-1蛋白的表达.结果:在结直肠正常黏膜、癌及淋巴结转移癌中Fascin-1蛋白表达差异有显著性(χ2=30.917,P=0.000).两两比较发现,癌组织Fascin-1表达比正常黏膜强(Z=-3.912,P=0.000),淋巴结转移癌组织表达比原发结直肠癌组织强(Z=-2.419,P=0.016);在结直肠癌组织中,伴发淋巴结转移的结直肠癌组织比未发生转移的结直肠癌组织Fascin-1表达明显增强,差异具有显著性(Z=-2.432,P=0.015);并且,Fascin-1蛋白表达水平与结直肠癌的浸润深度呈正相关(Z=-2.074,P=0.038),而与结直肠癌的分化程度无关(χ2=0.333,P=0.847).结论:Fascin-1蛋白表达与结直肠癌的浸润、转移密切相关,可作为结直肠癌浸润、转移的指标.更多还原

【Abstract】 AIM: To investigate the correlation between Fascin-1 expression and carcinogenesis and biological behavior of colorectal cancer (CRC). METHODS: The expression of Fascin-1 was examined in 80 specimens of CRC, 40 of paired normal colorectal mucosae and 37 of regional lymphatic metastases by immunohistochemical method. RESULTS: Fascin-1 was expressed heterogeneously among the normal colorectal mucosae, CRC and lymphatic metastases (χ2=30.917, P=0.000). Fascin-1 was higher expressed in CRC compared with normal colorectal mucosae (Z= -3.912, P=0.000), and Fascin-1 expression was significantly stronger in lymphatic metastases than that in primary CRC (Z=-2.419, P=0.016). Furthermore, Fascin-1 expression in CRC with lymph node metastasis was higher than that in CRC without lymph node metastasis (Z=-2.432, P=0.015). Expression levels of Fascin-1 protein, showing no correlation with the differentiation of CRC (χ2=0.333, P=0.847), was positively correlated with the invasive depth of CRC (Z=-2.074, P=0.038). CONCLUSION: Fascin-1 expression plays an important role in invasion and metastasis of CRC. Clinically it may be a useful indicator of the tumor invasion and metastasis in CRC.更多还原