【摘要】 目的:探讨大鼠在术后早期腹腔化疗的情况下,应用生物蛋白胶(FS)和谷氨酰胺(G ln)对结肠吻合口愈合的影响。方法:将32只大鼠随机分为四组,即对照组:于结肠吻合术后第1～3天,每天腹腔内注射0.9%NaC l 4mL;腹腔化疗组(5-FU组):于结肠吻合术后第1～3天,腹腔内注射5-氟尿嘧啶20 mL/kg(20 mg/mL);生物蛋白胶组(FS组):于结肠吻合术后,吻合口覆盖生物蛋白胶约1 mL,腹腔化疗同5-FU组;谷氨酰胺组(G ln组):手术和化疗同FS组,术后当天灌服G ln颗粒1 g/(kg.d)。观察吻合口评分、吻合口破裂压力和组织学情况。结果:G ln组和FS组吻合口破裂压力、吻合口愈合情况和生存率,明显高于5-FU组。结论:吻合口覆盖生物蛋白胶,应用G ln能明显促进腹腔化疗后结肠吻合口的愈合。更多还原

【Abstract】 Objective: To investigate the effects of fibrin glue(FS) and glutamine(Gln) on the healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil.Methods: Thirty two female Wistar rats were randomized into four groups.After resection of a 1-cm segment of the transverse colon,an end-end sutured anastomosis was performed.Then the rats were divided into control group,5-FU group,FS group,and Gln group.All rats were killed on the 8th postoperative day and the anastomoses were examined microscopically.The bursting pressure measurements were recorded and anastomoses were graded histologically.Results: The adhesion formation score was significantly higer in the rats of the 5-FU group than in the other groups.Bursting pressures were also significantly lower in the 5-FU group than in the other groups.Conclusion: The immediate postoperative intraperitoneal administration of 5-FU inhibited wound healing.However,FS and Gln can improve early healing of colon anastomoses after immediate postoperative intraperitoneal administration of 5-fluorouracil.更多还原