【摘要】 目的:对结直肠手术后病人应用肠道微生态制剂治疗的效果进行评价。方法:前瞻性、单盲、随机、对照临床试验。将32例结直肠中等以上手术的病人,随机分为试验组和对照组,每组各16例。试验组病人于术后第3天给予肠内营养+双歧杆菌/嗜酸性乳杆菌/粪链球菌(菌品名:金双歧),每天2次,每次4片,直至出院。对照组只给予肠内营养支持。观察病人术前及术后4～8d的胃肠道症状、生命体征、粪便性状及量和菌群比例等。结果:①胃肠道症状:两组病人术后恶心、呕吐、肠鸣音恢复等差异均无显著性意义(P>0.05),总腹胀天数、总腹痛天数在两组间差异有显著性意义(P<0.05)。②腹泻及腹泻评分:两组病人在术后第6天腹泻例数差异有显著性意义(P<0.05),总腹泻天数、总腹泻人数两组间差异有显著性意义(P<0.05)。两组病人腹泻评分在术后第6天有显著性意义。③菌群比例:试验组病人菌群比例(杆菌/球菌)术后3次均比对照组高,术后第2次监测,两组间差异有显著性意义(P<0.05)。结论:在结直肠术后病人中,应用肠道微生态制剂可改善病人胃肠道症状、减轻腹泻严重程度和纠正肠道菌群失调。更多还原

【Abstract】 Objective: The study was designed to investigate the effect of intestine microecologic agents in postoperative patients with colorectal diseases. Methods: 32 patients undergoing the colorectal operation were randomized into the study group and the control group. Both groups received standard enteral nutrition. The study group received the intestine microecologic agents (golden bifido) from the 3rd day after the operation, but the control group didn’t receive golden bifido. The parameters including gastrointestinal symptom, diarrhea and diarrhea score, intestinal flora ratio were measured before and after the operation and the application of the agents. Results: ①Compared with the control group, the study group had less flatulence and abdominal pain(P<0.05). ② The study group had less occurrences of diarrhea on the 6th day after the operation(P<0.05). In the study group, the total occurrences and days of diarrhea were lower than those in the control group(P<0.05). ③Intestinal flora ratios were higher in the study group. Conclusion: The application of intestine microecologic agents in postoperative patients with colorectal diseases is beneficial in alleviating gastrointestinal symptom and correcting intestine flora disturbance.更多还原