【摘要】 目的观察拉米夫定(LAM)治疗慢性乙型肝炎(慢乙肝)过程中血清IFN-γ、IL-4等细胞因子的动态变化。方法用ELISA方法分别检测117例慢乙肝患者在LAM治疗前和治疗后第13、26、39、52周时的血清IFN-γ和IL-4水平。结果LAM治疗后完全应答组IFN-γ/IL-4水平接近或高于对照组;部分应答组和无应答组IFN-γ/IL-4水平则低于对照组。结论LAM治疗慢乙肝过程中,随着治疗时间的延长,患者Th1类细胞因子IFN-γ水平逐渐增强;Th2类细胞因子IL-4水平逐渐减弱,提示LAM治疗慢乙肝不但抑制病毒繁殖,而且长时间治疗可增强Th1类细胞优势应答,抑制Th2类细胞功能。更多还原

【Abstract】 Objective To investigate serum levels of IFN-γ and IL-4 in chronic hepatitis B patients during lamivudine treatment. Methods The serum levels of INF-γ and IL-4 were determined by ELISA in 117 chronic hepatitis B patients before and during lamivudine treatment at week 13, 26, 39 and 52. Results The levels of IFN-γ and IL-4 in full response group during lamivudine treatment were close to or higer than those in the control group; those in partial response group and non- response group were less than those in the control group. Conclusion The levels of IFN-γ in chronic hepatitis B patients increased and those of IL-4 decreased little by little during longer duration of lamivudine treatment. This suggestes that long-term lamivudine treatment of chronic hepatitis B can not only stop HBV replication but also enhance the expressions of Th1 cytokines and inhibit those of Th2 cytokines.更多还原