【摘要】 确定了无水乙醇钠催化下,丙二酸二乙酯与烯丙基氯反应得到烯丙基丙二酸二乙酯(Ⅰ),再经皂化、脱羧制备4-戊烯酸(Ⅱ)的较佳合成工艺:丙二酸二乙酯与烯丙基氯的摩尔比为1.2∶1,加热回流3h;皂化时间5h;4-戊烯酸总产率为53.2%.产物4-戊烯酸的结构经质谱、红外光谱、核磁共振进行了确认.更多还原

【Abstract】 Catalyzed by anhydrous sodium ethoxide,diethyl malonate reacted with allyl chloride to give diethyl allylmalonate(Ⅰ);then through saponification and decarboxylation of(Ⅰ),the flavor of 4-pentenoic acid(Ⅱ) was obtained.Following the optimal technology,the mole ratio of diethyl malonate to allyl chloride in 1.2∶1,the refluxing time of 3 h;and the saponification time of 5 h;the overall yield of 4-pentenoic acid was up to 53.2%.The structure of 4-pentenoic acid was confirmed by MS,IR and 1HNMR.更多还原