【摘要】 目的探讨同型半胱氨酸(Hcy)与颈动脉粥样硬化及脑梗死之间的关系。方法观察90例脑梗死患者和40例对照者,用循环酶法测定血清Hcy水平,用彩色多普勒超声检查颈动脉颅外段。采用非条件Logistic回归分析颈动脉粥样硬化的危险因素及与脑梗死的关系。结果脑梗死组Hcy浓度为22.32(17.05～27.18)μmol/L,显著高于对照组的12.71(9.63～16.48)μmol/L(P﹤0.001),颈动脉粥样硬化与脑梗死相关;校正了传统危险因素后,Hcy仍然与颈动脉粥样硬化相关。结论血清Hcy升高可能通过促进颈动脉粥样硬化,导致脑梗死的形成。更多还原

【Abstract】 Objective To investigate the relationship between homocysteine(Hcy) level and carotid artherosclerosis in cerebral infarction patients. Methods In 90 cerebral infarction patients and 40 healthy controls,serum homocysteine level was measured by cyclophorase assay,carotid artherosclerosis was determined by the use of the duplex ultrasonography. Logistic regression was performed to analyze the relationship between homocysteine,carotid artherosclerosis and cerebral infarction. Results The fast homocysteine level in the patient group was 22.32(17.05～27.18)μmol/L,significantly higher than that in the control group 12.71(9.63～16.48)μmol/L (P﹤0.001);carotid artherosclerosis was related to cerebral infarction; homocysteine level was related to the carotid artherosclerosis and cerebral infarction even after controlling for other traditional risk factors. Conclusions Serum homocysteine is the independent risk factor for cerebral infarction,and artherosclerosis is the probable linkage.更多还原