【摘要】 目的探讨P300靶刺激中的P3波用于评估皮质下缺血性血管认知功能障碍(VCI)的价值。方法测试皮质下缺血性血管病患者痴呆(SIVD)组43例、非痴呆的认知功能障碍(VCND)组34例与认知正常组38例P3波潜伏期和波幅的变化。结果在Cz和Pz区域,与正常对照组比较,SIVD组的潜伏期[(400.43±3.57)ms、(309.76±3.96)ms]明显延长(P﹤0.05),波幅[(4.23±0.34)μV、(5.87±1.54)μV]明显降低(P﹤0.05)。在Cz和Pz区域,VCND组的潜伏期[(400.26±5.55)ms、(396.12±5.23)ms]较正常对照组均明显延长(P﹤0.05);而波幅[(18.22±0.29)μV、(8.85±0.2)μV]较正常对照组在Cz区域明显降低(P﹤0.05),但在Pz区域无显著性差异。结论P3波可作为诊断SIVD的重要客观指标;P3波潜伏期作为皮质下缺血性VCND的辅助诊断指标可能更为敏感。更多还原

【Abstract】 Objective To investigate the value of P3 wave of target stimulus P300 in the appraisal of subcortical ischemic vascular cognitive impairement. Methods P3 latency and amplitude were recorded and analysed in 43 subcortical ischemic vascular dementia(SIVD),34 subcortical ischemic vascular cognitive impairement with no dementia and 38 subcortical ischemic vascular disease with normal cognition. Results The dementia group showed higher latencies (P﹤0.05)and lower amplitudes (P﹤0.05)than normal group in both Cz and Pz areas. Cognitive impairement with no dementia group showed higher latencies (P﹤0.05) than normal group in both Cz and Pz areas,only a lower amplitude (P﹤0.05)in Cz area but no significant difference(P﹥0.05) in Pz area. Conclusions P3 can be used as an important parameter in diagnosing of SIVD. P3 latency is more sensitive for the early diagnosis of subcortical ischemic vascular cognitive impairement.更多还原