【摘要】 为了探讨胃癌患者术后血清CA19-9、CA72-4和MG7-Ag检测的临床意义,本文对170例Ⅲ期胃癌行根治术的患者进行术前及术后每两个月检测患者血清CA19-9、CA72-4和MG7-Ag,术后定期进行胸片、B超和CT等影像学检查,并对疑有局部复发的患者行胃镜检查。结果表明:全组中有101例患者发现了复发(其中血源性复发83例,局部复发18例)。CA19-9、CA72-4和MG7-Ag对复发患者阳性率分别为62.4%、67.3%和59.4%;三项联合检测的阳性率为95.0%,除MG7-Ag外,以上阳性率均显著高于术前(分别为48.5%,51.5%、57.0%和76.4%)。标志物出现异常的时间比影像学发现病灶早14个月至晚4个月(中位时间为4.2±2.5个月)。三项标志物中,CA19-9异常与复发后的生存时间有显著相关性。联合检测CA19-9、CA72-4和MG7-Ag有助于预测胃癌术后复发,而CA19-9可作为判断胃癌术后预后的独立因素。更多还原

【Abstract】 In order to explore the value of detection of serum CA19-9,CA72-4 and MG7-Ag in patients with gastric cancer after operation,170 patients with stage Ⅲ gastric cancer underwent radical gastrectomy were followed up.Serum levels of CA19-9,CA72-4 and MG7-Ag in patients were examined preoperatively and every 2 months postoperatively.The diagnostic imaging such as X-ray,computed tomography(CT) and ultrasonography were carried out in all patients regularly.The patients suspected with the regional recurrence also had gastroscopy examination.The results showed that recurrence of gastric cancer was observed in 101 patients(blood source recurrence 83,regional recurrence 18).The positive rate of CA19-9,CA72-4 and MG7-Ag in patients with recurrence was 62.4%,67.3%,59.4%respectively.The positive rate of combined detection of CA19-9,CA72-4 and MG7-Ag was 95.0%.All of these values were significantly higher than those of preoperative results(48.5%,51.5%,57.0% and 76.4% respectively),except for MG7-Ag.These tumor markers were detected positively between 14 months before recurrence detected by diagnostic imaging and 4 months after detected by diagnostic imaging(mean of 4.2±2.5 months before detection by diagnostic imaging).The detection of serum CA19-9,CA72-4 and MG7-Ag might be regarded as clinical significance for predicting and monitoring the recurrence of gastric cancer after operation,and CA19-9 can be used as an independent predict prognostic factor.更多还原