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海洋细菌Bacillus Marinus化学成分分离和结构鉴定

Isolation and Structure Identification of Chemical Constituents from Marine Bacteria Bacillus Marinus

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【Author】 YIN Hong-quan1,2,TIAN Li3,4,FU Hong-wei2,HUA Hui-ming2,ZHANG Qing-shan1,PEI Yue-hu2(1.School of Chemical Engineering and Environment,Beijing Institute of Technology,Beijing 100081,China;2.School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang,Liaoning 110016,China;3.Department of Biological Pharmacy,Qingdao University of Science and Technology,Qingdao,Shandong 266042,China;4.Lab of Bioactivity,First Institute of Oceanography,State Oceanic Administration,Qingdao,Shandong 266061,China)

【机构】北京理工大学化工与环境学院；青岛科技大学生物制药系；沈阳药科大学中药学院；沈阳药科大学中药学院北京100081；辽宁；沈阳110016；山东青岛266042；国家海洋局第一海洋研究所生物活性室；山东；青岛266061；辽宁沈阳110016；北京100081；

【摘要】研究Z3-1号海洋细菌bacillus marinus发酵液的化学成分.利用硅胶、Sephadex LH-20柱色谱及重结晶等方法进行分离纯化,根据理化性质和1H-NMR,13C-NMR等波谱数据进行结构鉴定.得到8个化合物,分别鉴定为环(甘氨酸-脯氨酸)二肽、环(丙氨酸-脯氨酸)二肽、环(亮氨酸-脯氨酸)二肽、对羟基氧代吡啶、尿嘧啶、胸腺嘧啶、β-谷甾醇和尿素.以上化合物均为首次从该种细菌发酵液中分离得到.更多还原

【Abstract】 Studies the chemical constituents of the fermentation liquid from marine bacteria bacillus marinus(No.Z3-1).The compounds were isolated by column chromatography on silica gel,Sephadex LH-20 and recrystallization.Their structures were determined on the basis of physico-chemical properties and spectroscopic methods such as 1H-NMR and 13C-NMR.Eight compounds separately were identified as cyclo-(Gly-Pro) dipeptide,cyclo-(Ala-Pro) dipeptide,cyclo-(Leu-Pro) dipeptide,4-hydroxy-1-oxy-pyridine,uracil,thymine,β-sitosterol and urea.These compounds were obtained from bacillus marinus for the first time.更多还原

【关键词】药物化学；成分分离；结构鉴定；海洋细菌； bacillus marinus；
【Key words】 medicinal chemistry； constituent isolation； structural identification； marine bacteria； bacillus marinus；

【基金】国家“八六三”计划项目(2001AA624020)

【文献出处】北京理工大学学报 ,Transactions of Beijing Institute of Technology , 编辑部邮箱 ,2007年05期

【分类号】R284
【被引频次】15
【下载频次】325

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