【摘要】 目的探讨山东半岛地区汉族绝经女性雌激素受体α(ESRα)基因多态性与原发性骨质疏松症的关系。方法选取106例长期居住于山东半岛地区的绝经且患有骨质疏松症的汉族妇女(骨质疏松组)及82例绝经且未患骨质疏松症的汉族妇女(对照组),观察其ESRα基因多态性与骨质疏松症的关系。结果骨质疏松组和对照组基因型及等位基因频率分布比较,差异无显著性(χ2=0.025～5.979,P>0.05)。结论山东半岛地区绝经女性ESRα基因多态性与原发性骨质疏松症不存在相关性。更多还原

【Abstract】 Objective To investigate the relationship between the polymorphism of α-gene of estrogen receptor(ESR-α gene) and osteoporosis in postmenopausal women of Han people in Shandong peninsula. Methods Postmenopausal women with osteoporosis(osteoporosis group,n=106) and postmenopausal women without osteoporosis(control group,n=82) were included in this study.The relationship between the polymorphism of ESR-α gene and osteoporosis was evaluated. Results Genotype and the distribution of allele frequency were not found significantly different between osteoporosis group and control group(χ2=0.025-5.979,P>0.05). Conclusion There is no association between the polymorphism of ESR-α gene and osteoporosis in postmenopausal women of Han people in Shandong peninsula.更多还原