【摘要】 以高压液相色谱(HPLC)法为定量手段研究了妥曲珠利在健康和柔嫩艾美尔球虫感染肉鸡体内的药动学特征。30日龄艾维茵肉鸡30只,随机分为健康组和柔嫩艾美耳球虫感染组和感染对照组。健康组和柔嫩艾美耳球虫感染组灌服2.5%妥曲珠利溶液(8 mg.kg-1)后,血浆药物浓度-时间数据符合一级吸收二室开放模型,健康组和感染组主要动力学参数分别为:t1/2α为(4.31±0.85)和(4.29±1.03)h,t1/2β为(23.81±2.81)和(23.76±3.31)h,Vd为(0.39±0.09)和(0.40±0.07)L.kg-1,CL(s)为(0.05±0.01)和(0.05±0.01)L.h-1,AUC为(174.15±34.09)和(165.14±23.71)μg.h.mL-1。该结果表明球虫感染肉鸡单次灌服2.5%妥曲珠利溶液后药动学特征与健康鸡比较无显著差异,说明柔嫩艾美耳球虫感染对妥曲珠利在肉鸡体内的药动学过程无明显影响。更多还原

【Abstract】 The pharmacokinetics of toltrazuril were investigated in 10 healthy and 10 E.tenella coccidia-infected Avine broiler chickens by HPLC method.The pharmacokinetic characteristics of toltrazuril in healthy and infected chickens after single oral administration of 8 mg·kg-1 were best described by an open two-compartment model with first order absorption rate.The main pharmacokinetics parameters were as follows:t1/2α(4.31±0.85) and(4.29±1.03) h,t1/2β(23.81±2.81) and(23.76±3.31) h,Vd(0.39±0.09) and(0.40±0.07) L·kg-1,CL(s)(0.05±0.01) and(0.05±0.01) L·h-1,AUC(174.15±34.09) and(165.14±23.71) μg·h·mL-1.The results showed that the main pharmacokinetics parameters of chickens were not significantly effected by E.tenella coccidia infection.更多还原