【摘要】 目的观察中药降糖补肾方对2型糖尿病(T2DM)相关炎症因子的影响,并探讨其治疗糖尿病的作用机理。方法将入选的64例2型糖尿病患者随机分为治疗组34例,对照组30例,两组均予糖尿病教育、合理饮食并常规应用西药降血糖,治疗组加用降糖补肾方(由狗脊10g川断10g女贞子15g旱莲草15g地骨皮15g生黄芪15g生地15g葛根12g黄连5g桑白皮10g知母6g等组成),每日1剂,水煎分2次服,两组疗程均为4周。测定两组治疗前后空腹血糖(FBG)、胰岛素(FINS)、白细胞介素6(IL6)、肿瘤坏死因子α(TNFα)、C反应蛋白(CRP)含量,计算胰岛素敏感指数(ISI)及两组治疗前后中医临床症状积分。结果治疗后两组FBG和中医临床症状积分均下降(P<0.05,P<0.01),其中治疗组中医临床症状积分较对照组下降明显,差异有显著性(P<0.01);治疗组FINS、IL6、TNFα、CRP含量治疗后均显著下降、ISI明显升高,且优于对照组(P<0.05)。结论健脾补肾、养阴清热中药降糖补肾方能有效改善胰岛素抵抗,减轻患者临床症状,其作用机理可能与调节炎症因子的产生、抑制炎症反应有关。更多还原

【Abstract】 ObjectiveTo observe the effect of Jiangtang Bushen Recipe (JBR) on inflammatory cytokines in patients with type 2 diabetes mellitus (T2DM), and explore its therapeutic mechanism. MethodsSixty-four patients with T2DM were randomly divided into the treated group (n=34) and the control group (n=30). Education course, dietary treatment and conventional hypoglycemic agent were given to both groups, and JBR, mainly composed of Cibot Rhizome, Radix Dipsaci, Glossy Privet Fruit; Ecliptae Herba, Radicis Lycii, Radix Astragali, Rehmannia Dride Rhizome, etc., was given additionally to patients in the treated group, one dose a day for 4 weeks by boiled water and taking in two times. Fasting blood glucose (FBG), fasting insulin (FINS), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured, and insulin sensitive index (ISI) and clinical TCM symptom score were calculated before and after treatment. Results After treatment, the clinical symptom score dropped in both groups (P<0.01), and it was lower in the treated group than that in the control group (P<0.01). At the same time, serum levels of FINS, CRP, TNF-α and IL-6 decreased and ISI increased significantly, the effect showed in the treated group was also superior to that in the control group (P<0.05). Conclusion JBR, which could tonify Pi and Shen,nourish Yin and clear away heat, can improve insulin resistance and alleviate clinical symptoms of T2DM patients, the mechanism may be related with its actions in regulating the production of inflammatory cytokines and inhibiting inflammatory reaction.更多还原