【摘要】 目的探讨麝香注射液对急性脑梗塞患者炎症反应的影响及临床治疗效果。方法42例急性脑梗塞患者随机分为2组,对照组21例,采用常规药物治疗;麝香组21例,采用麝香注射液加常规药物治疗。动态观察患者入院时、病程第7天、14天时的血单核细胞CD54分子(MCCD54)的表达、血清可溶性血管细胞黏附分子1(sVCAM1)水平及临床治疗结果,并与21名健康人比较。结果两组急性期患者MCCD54表达率、sVCAM1水平显著升高(P<0.01),第7天呈现峰水平,第14天时显著回落,且两项指标在第14天以麝香组为低(P<0.01);MCCD54表达率与sVCAM1水平呈正相关性(P<0.01);治疗后神经缺损程度评分以麝香组改善明显(P<0.05);显愈率也高于对照组(P<0.05)。结论麝香注射液对脑梗塞炎症反应具有抑制作用,并通过这种作用,提高了疗效。更多还原

【Abstract】 ObjectiveTo investigate the clinical efficacy of Shexiang Injection (SI) on inflammatory reaction in patients with acute cerebral infarction (ACI). MethodsForty-two patients with ACI were randomly divided into two groups, 21 in each group. The control group treated with conventional therapy and the SI group treated with conventional therapy plus SI. Besides, 21 healthy people were arranged in the normal group for control. Expression of CD_ 54 of mononuclear cell (MC-CD_ 54) and serum level of soluble vascular cell adhesion molecule-1 (sVCAM-1) were determined and the clinical efficacy was observed dynamically before treatment and on the 7th, 14th day of the course. ResultsLevels of MC-CD_ 54 expression and sVCAM-1 in the ACI patients increased obviously (P<0.01), reached the peak on the 7th day, and declined obviously on the 14th day in both groups, however, the lowering in the SI group was more significant than that in the control group (P<0.01); and positive correlation was shown between these two indexes (P<0.01). After treatment, score of neural defect was improved more significantly (P<0.01), and the markedly effective and curative rate was higher in the SI group than those in the control group (P<0.05), respectively. ConclusionSI could inhibit the subsequent inflammatory reaction, and thus improve the clinical efficacy of conventional therapy in treating patients with ACI.更多还原