【摘要】 目的探讨川芎嗪、异丙酚联合使用对围手术期缺血-再灌注损伤肝脏的保护作用及其机制。方法选择36例肝癌手术患者,随机分为对照组、川芎嗪组、异丙酚组和川芎嗪加异丙酚组。动态观察超氧化物歧化酶(SOD)活性、脂质过氧化物(LPO)浓度、血栓素B2(TXB2)/6-酮-前列腺素F1α(6-keto-PGF1α)比值、谷丙转氨酶(ALT)活性及肝细胞形态学的变化。结果与对照组比较,川芎嗪组、异丙酚组、川芎嗪加异丙酚组血浆SOD活性均明显增高(P<0.05或P<0.01),LPO浓度、TXB2/6-keto-PGF1α比值及ALT活性均显著下降(P<0.05或P<0.01),肝细胞形态学异常改变明显减轻。结论川芎嗪联用异丙酚可通过降低体内氧自由基水平、减轻脂质过氧化反应,纠正血栓素A2与前列环素失衡,对围手术期缺血-再灌注损伤肝脏发挥较明显的保护作用。更多还原

【Abstract】 ObjectiveTo explore the protective effect a nd mechanism of ligu strazine （LGT） and propofol （PRO） on peri-operational liver ischemia-re pe rfusion injury （HIRI）. MethodsThirty-six patients sche duled for hepatic surgery were randomly divided into the control group, the LGT group, the PRO group and the LGT+PRO group, 9 patients in each group. Changes of superoxide dismutase （SOD）, lipid peroxide （LPO）, ratio of thromboxane B₂ （TXB₂） an d 6-keto-prostaglandin F_1α(6-keto-PGF_1α), alanine aminotransfe rase （ALT） activity, and the ultrastructure of liver tissue were dynamically observed. ResultsCompared with the control group, SOD activity was si gnificantly higher, LPO concentration, TXB₂/6-keto-PGF_1α ratio and A LT value were significantly lower （P<0.05 and P<0.01） in the LGT group, the PRO group and the LGT+PRO group during HIRI, with the abno rmal changes of hepatic ultrastructure 25 min after reperfusion si gnificantly alleviated. in the three treated group. Conclusion Combination of ligustrazine and propofol shows protective ef fect on liver by decreasing oxygen free radical level, reducing lipid per oxidation and adjusting TXA₂/PGI₂ imbalance after hepatic ischemia-reperfus ion in patients undergoing hepatic cancer surgery.更多还原