【摘要】 一水合-L-(2R,3R)-(-)-二苯甲酰酒石酸是重要的手性药物拆分剂,但其价格昂贵,因此,我们对其合成方法进行了研究.采用2R,3R-酒石酸、苯甲酸、亚硫酰氯为原料,苯甲酰化伴随脱水反应生成二苯甲酰酒石酸酐,然后酸酐水解得到目标产物,以酒石酸计,一水合二苯甲酰酒石酸的总收率为70.9%,该方法采用亚硫酰氯将反应生成的苯甲酸酰化后重新利用,反应收率高、后处理简便.产物结构经旋光度的测定,与报道结果一致.该方法工艺条件易于控制,污染少.更多还原

【Abstract】 The preparation of chiral drugs is a significant field of new drug research and application at present.L-(2R,3R)-(-)-dibenzoyl tartaric acidmonohydrate is an important resolute reagent with a high price.So,it is vital to study the improvement of its synthesis. Dibenzoyl tartaric anhydride was synthesized from tartaric acid,benzoic acid and thionyl chloride as raw material by benzoylation and dehydration.Then,dibenzoyl tartaric acid monohydrate could be obtained by hydrolysis.The total yield reached 70.9% calculated from tartaric acid. Benzoic acid that created by the reaction could be re-applied by benzoylation with thionyl chloride in this process.The process has the advantages of high yield and simple operation.Structure of the resultants was identified by optical rotation which agreed with the literature.The process condition was easy to control,and there was little pollution.This method had a good prospect of industrial application.更多还原