【摘要】 目的:研究灵芪蠲肝液对急性肝损伤的保护作用机制。方法:用硫代乙酰胺复制大鼠急性肝损伤模型,检测肝功能、一氧化氮(NO)含量以及肝组织匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)水平并取肝组织做病理检查。结果:硫代乙酰胺急性肝损伤时,灵芪蠲肝液能使血清ALT、AST活性、TB il、MDA、NO水平明显降低,升高SOD水平;病理检查发现其能减轻肝细胞变性、坏死,减少炎细胞浸润。结论:灵芪蠲肝液通过减少氧自由基的产生,减少NO的产生,从而保护肝细胞膜。更多还原

【Abstract】 Objective: To observe the mechanism of Lingqijuangan Liquor(LQL) on acute hepatic injury.Methods: Acute hepatic injury was induced by thioacetamide.Then hepatic functions and the levels of serum nitric oxide(NO) and 10%liver homogenates’ malonyldialdehyde(MDA) and superoxide dismutuse(SOD) were detected.Take liver tissue to do pathological examination.Results: Compaired with model group,blood serum ALT and AST activities,TBil and NO levels and MDA levels in homogenates were significantly decreased by LQL;and SOD levels were obviously increased by LQL when livers were acute injuried.Pathological examination found that LQL can lighten hepatic cell denaturalization and putrescence and reduce inflammation cell infiltration.Conclusion: LQL can lighten the thioacetamide induced acute liver injury by decreasing production of oxygen free radicals and reducing production of NO so as to protect liver cellular membrane更多还原