【摘要】 目的研究氯化锰对小鼠精子畸形率的影响,并探讨其时间-效应关系和剂量-效应关系。方法将雄性小鼠随机分为3个染锰组和1个对照组,给予各组小鼠腹腔注射7.5、15.0、30.0mg/kg氯化锰和生理盐水,分别于染锰第3、7、14、28、56天处死各组小鼠5只,观察精子畸形率。结果各染锰组分别于染锰不同时间出现精子畸形率升高,且随着染锰剂量的增加和时间的延长而逐渐加重。结论氯化锰可导致精子畸形率升高,且有一定的时间-效应和剂量-效应关系。更多还原

【Abstract】 Objective To study the effects of manganese chloride exposure on ratio of deformity in mice,and explore the dose-effects andtime-effects.Methods The study mice were divided into 3 treatment groups with manganese chloride（7.5,15.0,30.0mg/kg） and 1 control group with NS.The ratio of deformity of sperm was investigated after 5 different time（3,7,14,28,56d） i.p.administration MnCl₂（7.5,15.0,30.0mg/kg）.Results Results shows the ratio of deformity of sperm were significantly increased after different time in exposed groups respectively.Conclusions It is suggested that Mncl₂ might lead the ratio of deformity to increase in mice,and there existed dose-effects and time-effects.更多还原