【摘要】 目的探讨G蛋白β3亚单位基因C825T多态性与蒙古族人群原发性高血压患者之间的关系。方法采用Se-quenom系统检测分析方法检测124例健康人和143例高血压患者的G蛋白β3亚单位基因C825T多态性。结果(1)蒙古族人群GNB3基因C825T位点CC、CT、TT基因型频率在高血压组和正常血压组分别为0.48、0.41、0.11和0.43、0.47、0.10,差异无显著性(χ2=0.162,P=0.688;OR:1.176,95%CI 0.533~2.592);C、T等位基因频率在高血压组和对照组分别为0.69、0.31和0.67、0.33差异无显著性(χ2=0.094,P=0.759;OR:0.945,95%CI 0.657~1.358)。(2)蒙古族人群GNB3基因C825T位点CC、CT、TT基因型频率在单纯收缩压增高组和正常血压组分别为0.57、0.35、0.08和0.43、0.47、0.10,差异无显著性(χ2=0.733,P=0.392;OR:1.957,95%CI 0.623~6.143);C、T等位基因频率在单纯高血压组和对照组分别为0.74、0.26和0.67、0.33,差异无显著性(χ2=2.133,P=0.144;OR:0.697,95%CI 0.428~1.133)。结论G蛋白β3亚单位基因C825T位点与蒙古族人群原发性高血压的发生可能无关,不是蒙古族人群原发性高血压的遗传标志。更多还原

【Abstract】 Objective: To analyze the association between C825T polymorphisms of G proteinum′s β3 subunit gene and Mongolian patients with essential hypertension(EH).Methods: Sequenom system was used to test G proteinum′s β3 subunit gene C825T polymorphisms of 124 healthy adults and 143 patients with EH.Results : ⑴ The CC,CT,TT genetype frequencies of G proteinum′s β3 subunit gene C825T site were 0.48,0.41,0.11 in mongol nation patients with EH and 0.43,0.47,0.10 in healthy adults,there were not significent difference in two groups(χ~2=0.162,P=0.688;OR:1.176,95% CI 0.533-2.592);the frequencies of C,T allele were 0.69,0.31 in patients groups and 0.67,0.33 in healthy groups,there were not significent difference in two groups too(χ~2 =0.094,P=0.759;OR:0.945,95% CI 0.657-1.358).(2)The CC,CT,TT genetype frequencies were 0.57,0.35,0.08 in simple high contractive pressure groups and 0.43,0.47,0.10 in normal pressure groups,two groups had no significent difference(χ~2=0.733,P=0.392;R:1.957,95% CI 0.623-6.143);the frequencies of C,T allele were 0.74,0.26 in simple high contractive pressure groups and 0.67,0.33 in normal pressure groups,two groups had no significent difference too(χ~2=2.133,P=0.144;OR:0.697,95% CI 0.428-1.133).Conclusion:C825 T site of G proteinum′s β3 subunit gene may be not related to Mongolian patients with EH,it was not genetic mark of EH.更多还原