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Y染色体长臂与近端着丝粒染色体易位的遗传学分析
Cytogenetic analysis of the translocation between the heterochromatic region of the long arm of the Y chromosome and the short arm of an acrocentric chromosome.
【摘要】 目的应用荧光原位杂交技术对4例染色体核型为15p+的患者进行分析。方法经细胞遗传学(G显带和C显带)发现染色体核型为15p+的患者选用Yq12为探针进行荧光原位杂交。结果15号染色体短臂的额外物质为Y染色体长臂末端的结构异染色质。结论FISH方法可帮助确定一些来源不明的额外染色体物质。
【Abstract】 Objective: This article is to analyze the chromosomal karyotypes of 4 patients with 15p+.Methods: Chromosomal analysis were performed in 4 patients by GTG /CBG-banding and Fluorescent in situ hybridization(FISH).Results: The positive DA-DAPI staining of 15p confirmed that the extra material came from Yqh at the pseudoautosomal region of Yq.Conclusions: These cases demonstrates the usefulness of molecular techniques in the investigation of rare chromosomal rearrangements.
- 【文献出处】 中国优生与遗传杂志 ,Chinese Journal of Birth Health & Heredity , 编辑部邮箱 ,2006年11期
- 【分类号】R394
- 【被引频次】1
- 【下载频次】138