【摘要】 目的探讨胎盘生长因子(PLGF)及其受体血管内皮生长因子受体-1(VEGFR-1)与子宫内膜异位症(endom etriosis,EMS)发病的相关性。方法用免疫组织化学染色法检测28例子宫内膜异位症患者的在位子宫内膜和异位子宫内膜(增生期、分泌期各14例),以及28例正常子宫内膜(增生期15例,分泌期13例)中PLGF及其受体VEGFR-1的表达。结果PLGF、VEGFR-1在各组内膜中均有表达,分泌期表达高于增生期,有显著差异。EMS的异位子宫内膜中的表达显著高于其在位子宫内膜和正常子宫内膜;EMS的在位子宫内膜和正常子宫内膜之间比较无明显差异。结论PLGF、VEGFR-1可能参与子宫内膜异位症的发病过程。更多还原

【Abstract】 Objective: To investigate the expression of PLGF and VEGFR-1 in endometriosis.Methods: Expression of PLGF and VEGFR-1 in ectopic and eutopic endometrium of endometriosis was assessed by the immuno-histochemistry.Results: Expression of PLGF and VEGFR-1 in ectopic endometrium group were significant higher than that in euptic endometrium group and normal endometrium group.Conclusion: The higher expression of PLGF and VEGFR-1 in ectopic endometrium with endometriosis indicates they may play a important role in the pathophysiology and development of endometriosis.更多还原