【摘要】 目的探讨复方地归胶囊对糖尿病大鼠糖脂水平紊乱的影响。方法大鼠腹腔注射链佐菌素(50mg·kg-1)造成糖尿病模型,复方地归胶囊高、中、低剂量组分别以2.4,1.2,0.6g·kg-1d-1灌胃,连续90d,测定全血血糖、糖化血红蛋白以及血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)和一氧化氮(NO)、总抗氧化能力(T-AOC),并测定胰岛素和进行胰腺组织学观察。结果给药后2h复方地归胶囊可降低糖尿病大鼠血糖水平,给药90d后能降低血红蛋白糖化率,对TG、LDL-C、NO水平有明显的降低作用,对T-AOC有显著的升高作用;并促进胰岛细胞修复增生,对胰岛素的分泌也有一定促进作用。结论复方地归胶囊有降低糖尿病大鼠血糖、调节血脂紊乱、保护和修复胰岛细胞的作用。更多还原

【Abstract】 Objective To study the effects of Compound Di Gui Capsule (CDGC) on the levels of glucose and lipid in diabetic rats.Methods Rats models with diabetes mellitus were induced by intraperitoneal injection of streptozotocin (50mg·kg-1).Then the diabetic rats were divided into different groups at random.CDGC groups were given CDGC in the dosages of 2.4,1.2,0.6 g·kg-1·d-1 respectively by gastric gavage for 90 d.Levels of whole blood glucose,glycosylated hemoglobin,total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C),nitric oxide (NO),total antioxidation capacity (T-AOC) were determined.The insulin level and the pathological changes of pancreatic tissues were also observed.Results The glucose level of diabetic rat was decreased 2h after administration.After administration of CDGC for 90d,the glycosylated hemoglobin,TG,LDL-C and NO were markedly decreased,islet βcells were protected and restored,and the insulin level and T-AOC were increased.Conclusion CDGC can regulate the metabolism of glucose and lipid in diabetic rats,and can protect and restore the pancreatic islet cells.更多还原