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中药泽泻质量控制方法的研究

Studies on Quality control for Rhizoma Alismatis

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【作者】 巩丽萍王少云侯准桑立红

【Author】 GONG Liping, WANG Shaoyun, HOU Zhun, SANG Lihong( College of Pharmacy, Shan Dong University,Ji′nan 250012)

【机构】 山东大学药学院山东大学药学院 济南250012济南250012

【摘要】 目的建立中药泽泻的质量控制方法。方法采用薄层色谱法对泽泻进行定性鉴别,采用高效液相色谱法-蒸发光散射检测器(HPLC-ELSD)对泽泻中泽泻醇B-23乙酸酯进行含量测定。结果泽泻的薄层鉴别图谱斑点清晰;泽泻醇B-23乙酸酯在4.4~110.0μg/mL范围内有良好线性关系,r=0.9992(n=5),平均加样回收率为98.98%(n=9),RSD为1.3%。结论该方法操作简便,结果准确,重现性好,可用于中药泽泻的质量控制。

【Abstract】 Objective To establish a method for the quality control of Rhizoma Alismatis. Methods The samples of Rhizoma Alismatis were identified with TLC and the content of alisol B-23-acetate in Rhizoma Alismatis was determined by HPLC-ELSD. Results The spots of TLC chromatogram of Rhizoma Alismatis was clear. A good linearity was in the range of 4.4~110.0 μg/mL of alisol B-23-acetate, r=0.999 2(n=5), and the average recovery rate was 98.98 %(n=9), RSD=1.3 %. Conclusion This method was simple, accurate and with a good reproducibility and can be used for the quality control of Rhizoma Alismatis.

【关键词】 泽泻泽泻醇B-23乙酸酯TLCHPLC-ELSD
【Key words】 Rhizoma Alismatis Alisol B-23-acetateTLCHPLC-ELSD
  • 【文献出处】 中药新药与临床药理 ,Traditional Chinese Drug Research & Clinical Pharmacology , 编辑部邮箱 ,2006年02期
  • 【分类号】R282.7
  • 【被引频次】12
  • 【下载频次】492
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