【摘要】 目的应用fMRI研究针刺太冲、合谷两穴位所致小脑响应的差异。方法37例健康志愿者随机分为4组,9例接受在太冲针刺,8例接受右侧太冲附近的假穴针刺,10例接受在合谷的针刺,10例接受右侧合谷附近的假穴针刺。在针刺时进行全脑功能成像扫描,用SPM2处理图像。结果发现针刺两穴位激活了小脑的不同区域:针刺太冲的激活了对侧小脑前叶,同侧小脑后叶下半月小叶;针刺合谷激活了对侧小脑后叶下半月小叶及同侧小脑后叶上半月小叶。两穴位针刺均未引起小脑的负激活。结论不同穴位引起的小脑激活区域不同,提示小脑在针灸不同穴位作用机制中具有特异性;小脑后叶可能是不同穴位作用的共同神经通路。更多还原

【Abstract】 Objective Functional MRI was used to explore the cerebellar respondings to acupuncture stimulation at right Liv3 (Taichong) and right LI4 (Hegu) respectively to investigate the distinction of cerebellar modulation by different acupuncture stimulation. Methods Thirty-seven healthy volunteers were randomly divided into four groups. Nine of them received real acupuncture at Liv3 and 8 received acupuncture at the corresponding sham point, while 10 received acupuncture at LI4 and 10 received the corresponding sham point acupuncture. Brain functional images of subjects were gotten during acupuncture stimulations. The functional data were analyzed with SPM2 software. Results We found acupuncture at Liv3 activated the contralateral anterior lobe of the cerebellum, ipsilateral inferior semi-lunar lobule of the posterior lobe. In compassion to Liv3, acupuncture at LI4 selectively activated contralateral inferior semi-lunar lobule and ipsilateral cerebellar superior semi-lunar lobule. Neither of the two acupuncture conditions did elicit negative activation in the cerebellum. Conclusion The results prompt the cerebellar responding to acupuncture stimulation mode be specific according to different acupoints, and the posterior lobe of the cerebellum may be the common neural pathway by which acupuncture stimulation modulate.更多还原